The late Steve Ditko didn't do a lot of amazon-characters, as he seemed to prefer male protagonists. Still, there are some notable ones.
One of the few starring characters was a 1970s one-shot named LIBERTY BELLE.
Then there was a sci-fi lady cop, Mellu Loron, who made things tough on starring hero Shade the Changing Man.
Also, two villainesses, the Dagger Lady from THE CREEPER, and the Huntress from THE DESTRUCTOR.